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甘草中的黄酮类成分及其抗肿瘤活性研究进展
甘草中的黄酮类成分及其抗肿瘤活性研究进展
黄雨婷1,迟宗良2,王姝梅3,吴红旗3,秦昆明2,李伟东1,4

1 南京中医药大学,南京 210023;2 南京海昌中药集团有限公司,南京 210061; 3 泰州市中医院,泰州 214504;4 江苏海昇药业有限公司,南京 210061
Research progress on Licorice flavonoids and their antitumor activities
(1 Nanjing University of Chinese Medicine, Nanjing 210023, China; 2 Nanjing Haichang Chinese Medicine Group Corporation, Nanjing 210061, China; 3 Taizhou Traditional Chinese Medicine Hospital, Taizhou 214504,China; 4 Jiangsu Haisheng Pharmaceutical Company Limited,Nanjing 210061,China)

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起始页:1532

摘要:[摘要] 甘草中的黄酮类化合物主要包括甘草素、异甘草素、甘草查尔酮A/E等,是甘草抗肿瘤的主要活性成分,能够通过阻滞细胞周期、影响肿瘤细胞凋亡基因调控、抑制肿瘤细胞血管生成等机制抑制肿瘤细胞的增殖,具有潜在的药用价值。其中对甘草素和异甘草素的研究最为深入,可进一步开发成为高效低毒的新型抗肿瘤药物。本文总结了甘草中含有的黄酮类成分,对近年来甘草中黄酮类化合物的抗肿瘤活性研究进行综述,并指出了该类化合物的研究方向及应用前景。

关键词:[关键词] 甘草;黄酮类;抗肿瘤

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Abstract:[Abstract] Flavonoid constituents from licorice have definite anticancer activities, including liquiritigenin, isoliquiritigenin, licochalcone A/E, and so on. They can inhibit the proliferation of tumor cells by blocking the cell cycle, influencing regulation of the apoptosis gene in the tumor cells, restraining the growth of blood vessel in tumor cells and have potential medicial values. Among the compounds, liquiritigenin and isoliquiritigenin are studied more profoundly, and they are promising to become efficient and hypotoxic antitumor drugs. This review summarizes the flavonoid constituents from licorice and the research of their antitumor activities in recent years, and the research direction and potential applications of such flavonoids compounds from licorice are also prospected.

Key words:[Key words] licorice; flavonoids; antitumor

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